The Lujiang-Zongyang volcano-structural depression resulted from the combined action of tectonism and volcanism. Its evolution progressed through five stages from 190 to 105 Ma B.P., during which nine types of metal and pyrite deposits were formed. These deposits show obvious regularities in the temporal-spatial distribution and have certain genetic relation, forming a minerogenetic series related to shoshonite within or around the volcano-structural depression on the basement that sank for a long period of time. This paper suggests a four-dimensional model of the formation and evolution of a typical volcano-structural depression and its related mineralizalion in a transition belt from the active margins to the inner part of a plate under alternating shear-compressive and shear-extensional stress conditions, but predominantly shear-extensional stress conditions.