The large- scale mineralization occurring in South China block far away from active continental margins during the Mesozoic. It formed two distinct metallogenic provinces: the eastern tungsten—tin high- temperature metallogenic province and the western gold—antimony—lead—zinc low- temperature metallogenic province, establishing globally significant metallogenic regions. The Nanling metallogenic belt in central South China block, is one of the most densely distribution regions of tungsten—tin polymetallic deposits in this world. The Nanling metallogenic belt has developed mineralized granites related to tungsten—tin deposits during Caledonian, Indosinian and Yanshanian periods. During the Indosinian period, the metallogenic activity in the region was obviously weaker compared with the Yanshanian period, and research on Indosinian period rocks in Nanling area is relatively lagging behind. This article compares the geochemical features between Indosinian tungsten—tin granites and barren oreforming granites in Nanling. By integrating previous research findings, it is found that high crystallized differentiation, low magnesium iron content, high REE+Y, Nb+Ta values, and mightily depletion of Ti and P.