Nanling metallogenic belt is one of the most important and distinctive polymetallic, nonmetallic and energy mine metallogenic belts in South China and even in China. There is a long- term history of the study in metallogenic law, however each summary of achievements is greatly benefit for the new round of prospecting. Based on the abundant previous research data, the regional geology of the Nanling metallogenic belt are summarized in this study. The spatial and temporal distribution and metallogenic characteristics of critical energy minerals (coal and uranium), non- ferrous minerals (tungsten, tin, molybdenum, bismuth, copper, lead—zinc, etc.), precious metals (gold and silver), rare metals and rare earth minerals, non- metallic minerals (fluorite) are discussed in detail. Moreover, the mineral deposits in Nanling metallogenic belt can be divided into 21 metallogenic series and 29 sub- series according to the 6 tectonic epoches of Precambrian, Caledonian, Variscan, Indonisian, Yanshanian and Himalayan. Thus, it provides a basis for further regional mineral exploration deployment and metallogenic prediction. In order to ensure the security of energy and resources, this study proposed the principle opinions on the block transfer of Nanling metallogenic belt and suggestions on prospecting in 15 large- scale resource bases such as Shizhuyuan, Xianghualing, Chongyu, Fuhezhong, Pingbao and Sannan, which provide scientific guidance for new round of prospecting.