Hetaoba uranium deposit in Inner Mongolia is located in the northern of Duolun volcanic basin in the middle section of Guyuan-Hongshanzi metallogenic belt, and has achieved good results in uranium and lead-zinc exploration in recent years. However, there has been a lack of precise dating of surrounding rocks in the study of diagenesis and mineralization time zones closely related to uranium mineralization, and there is still a blank in the research on the mineralization age of the newly breakthrough Huangliutiao mineral land in the eastern region. At the same time, there is a lack of research on the relationship between uranium and lead-zinc mineralization. These issues have constrained the efficiency of prospective forecasting and comprehensive exploration in the research area. This article summarizes the existing exploration results and conducts research on field geological phenomena, macroscopic laws, microscopic characteristics, chronology, three-dimensional spatial simulation. The U-Pb isotope age of zircon in the surrounding rock Rhyolite Porphyry is 140.7 ± 1.2 Ma (MSWD=0.7). The U-Pb isochron age of uranium ore in Huangliutiao area of the eastern region has been supplemented to 75.5 ± 7.4 Ma (MSWD=1.2), and it is comprehensively believed that the mineralization age of Hetaoba uranium deposit is 113.8 ~ 75.5 Ma. Identify the four stages of mineralization and alteration in the study area, namely the early alkaline metasomatism stage, the mid high temperature hydrothermal activity stage before mineralization, the uranium mineralization stage, and the post mineralization stage. Lead-zinc mineralization occurred earlier than uranium mineralization and belongs to the second stage product. Lead-zinc mineralization has a wider distribution range than uranium mineralization, but its intensity is relatively weak. No direct coupling relationship has been found between the two in three-dimensional space, but they are both controlled by tensile faults. Research suggests that Hetaoba deposit has a significant time difference in diagenesis and mineralization (26.9 ~ 65.2 Ma). The surrounding rocks have undergone long-term and multi-stage hydrothermal alteration processes, as well as multiple stages of uranium pre enrichment and mineralization. Ultimately, uranium deposit is formed during the tectonic hydrothermal alteration process of the main mineralization period, with the most closely related alteration to uranium mineralization being disseminated hematite and micro-fine pyrite, followed by purple black fluorite and powdery chlorite.