The Upper Ordovician Wufeng Formation to the Lower Silurian Longmaxi Formation in Luzhou area, the southern Sichuan Basin, constitute a key stratigraphic succession for marine deep- water shale gas exploration and development in south China. However, their burial- uplift history and gas- bearing evolution mechanisms remain poorly understood.Methods: The authors quantitatively reconstructed erosion volumes and maximum burial depths during the Yanshanian to Himalayan Periods in Luzhou area using sonic log analysis, and systematically investigated the coupling mechanisms between burial—thermal evolution and gas content based on the SDR adsorption model. Results:The present- day burial depths of the Wufeng Formation—Longmaxi formations range from 3500 to 5500 m, having reached maximum paleodepths of 6500~8000 m during the Late Cretaceous. Cenozoic tectonic uplift caused 2000~3000 m of erosion. Measured data demonstrate positive correlations between gas content and total organic carbon (TOC), porosity, and quartz mineral content, with average gas contents ranging from 0.66 to 3.93 cm3/g across different intervals. Total gas content peaked at 2.75~4.25 cm3/g during maximum burial, and despite Cenozoic uplift, modern gas content remains high at 2.75~4.00 cm3/g, revealing strong preservation conditions for deep shale gas.Conclusions: This study further reveals that compaction- induced porosity reduction during burial decreased total gas content, indicating that maximum paleodepth constrains the upper limit of gas content. During uplift, synergistic temperature—pressure reduction triggered dynamic re- equilibrium between adsorbed and free gas, causing initial slight increases followed by sustained declines in total gas content.