Barite is a national emerging strategic mineral resource. The Dahebian super-large barite deposit in Tianzhu, Guizhou, the largest barite resource base in China, has long seen its deep exploration hampered by insufficient understanding of the structural controls. Under the New Round of Strategic Action for Mineral Exploration Breakthroughs, the research team, through intensified investigation and comprehensive study, redefined the late-stage ore-disrupting effect of the ore-controlling fault F1 and revealed the critical control of siliceous rock thickness on orebody sedimentation. Based on these new insights, the cumulative newly identified barite resources in the hanging wall and footwall of the F1 fault within the Dahebian barite ore cluster have reached 174 Mt. For the first time, a blind barite orebody was discovered in the footwall of the F1 fault, significantly expanding the exploration potential and achieving a major breakthrough in barite prospecting. Simultaneously, it is predicted that the resource potential of this ore cluster exceeds 500 million tons, which will play a crucial supporting role in maintaining and enhancing the strategic position of barite resources in southeastern Guizhou.