Objective：Kalaqin Banner is located in the Au Ag Fe Cu Pb Zn metallogenic belt on the northern edge of the North China Platform, with superior geological conditions for mineralization. It is rich in lead-zinc, gold, and fluorite minerals, among which fluorite is a strategic mineral and its deposits are particularly noteworthy. The purpose of this article is to study the distribution characteristics, correlation, single element anomaly characteristics, and combination characteristics of anomalous elements in the Kalaqin Banner area. Based on this, the prospecting area is delineated and the next direction for prospecting is pointed out. Methods：The main research method used in this article is 1:50000 water sediment measurement, including field sample collection, sample testing (ICP-MS, ICP-AE, ES, XRF, AFS), data processing, and comprehensive analysis. Results：Research has found that fluorite, Pb, Zn, and Ag in the area have good prospecting potential. Four prospective areas with good prospecting potential have been identified, namely: Daxigou fluorite, lead-zinc silver polymetallic prospecting prospective area, Lazigou North fluorite prospecting prospective area, Lazigou South fluorite, lead-zinc silver polymetallic prospecting prospective area, and Qianaobaogou lead-zinc silver polymetallic prospecting prospective area. Analysis and suggestions for future work have been conducted on these areas. Conclusion：The entire region is enriched in elements such as F, Pb, Au, W, Ag, Mo, Zn, while elements such as Cu, Sn, Be, Li, Nb are depleted. F. Au and Bi elements have a high possibility of mineralization; Mo, Pb, and W elements have a high possibility of mineralization. Based on the abnormal characteristics of sediment in the water system and the screening and evaluation results, combined with the geological conditions of mineralization such as strata, structures, and magmatic rocks in the area, four prospecting areas have been delineated, which is of great significance for the future exploration of fluorite deposits in the area. In the semi-arid mid low mountain landscape area, the 1:50000 water system sediment measurement method for mineral exploration can effectively narrow the exploration range, quickly determine the exploration direction, delineate the exploration prospect area, and provide direct and reliable geochemical information for geological exploration.