In order to explore the seismogenic structure of the 2022 Luding magnitude 6. 8 earthquake and the migration patterns of strong earthquakes in the Xianshuihe fault zone. Methods: Based on existing literature and field geological surveys in the southern section of the Xianshuihe Fault Zone, this paper statistics the slip rate and historical earthquake data, and summarizes the migration patterns of strong earthquakes in the Xianshuihe Fault Zone in modern times, which is helpful for understanding the activities of the Xianshuihe Fault Zone. Characteristics and future seismic risk are of great significance. Results: The sliding rates of each section of the Xianshuihe fault zone are quite different; the seismogenic structure of the Luding earthquake was a left- lateral strike- slip event; the active period of strong earthquakes in the Sichuan—Yunnan region in modern history has the characteristics of “jumping” migration;Conclusions: ① The sliding rates of each section of the Xianshuihe fault zone are quite different. With Qianning as the boundary, the section from NW to SE shows a sliding characteristic of “first decelerating and then accelerating”. ② The seismogenic structure of the Luding earthquake The Moxi fault is a left- lateral strike- slip event. ③ The active period of strong earthquakes in the Sichuan and Yunnan regions in modern history has the characteristics of “jumping” migration. After the Daofu earthquake in 1981, the Xianshuihe fault zone entered a relatively quiet period, which lasted for 33 years. Since the Kangding earthquake in 2014, the Xianshuihe fault zone has once again entered a seismically active period. ④ The strong earthquake rupture of the Xianshuihe fault zone is not a “through- type” pattern of a single earthquake, but a gradual pattern of multiple earthquakes. The interaction between faults, especially the occurrence of large earthquakes, has a significant impact on the recurrence interval of strong earthquakes in the fault zone. Strong earthquakes in the same fault zone will also change the probability of subsequent earthquakes.