The Triassic granites in the West Kunlun-Pamir region is intricately linked to the evolution of the ancient Paleo-Tethys and metallogenesis of rare metals. We conducted a comprehensive study of the petrology, zircon U-Pb geochronology, major and trace element geochemistry, and zircon Hf isotopic analysis of two-mica granites from the Qiongrang, SW Muji, NE Pamir. Zircon U-Pb dating yield the age of around 211.6 Ma, suggesting two-mica granites from the Qiongrang emplaced at Late Triassic. The two-mica granites from the Qiongrang exhibit high levels of SiO2 (73.24% ~ 74.09%), Al2O3 (14.50% ~ 15.01%), and K2O (5.52% ~ 5.75%), and low TiO2 (0.15% ~ 0.18%) and MgO (0.30% ~ 0.37%). They also exhibit strongly peraluminous geochemical features (A/CNK = 1.12 ~ 1.15). The studied rocks are rich in Rb, Th, U, K and LREE, depleted in Sr, Ba, Nb, Ta, Ti, P and HREE, with obviously fractionation of LREE and HREE ((La/Yb)N = 44.62 ~ 54.58) and negative Eu anomaly (Eu/Eu* = 0.52 ~ 0.59), belonging to strongly differentiated S-granite, formed by the dehydration melting of mica from metamudstone sources. The zircon εHf(t) value of two-mica granites from the Qiongrang from -7.93 to -0.91, and the zircon εHf(t) value of the Dahongliutan granites range from -8.8 to -1.4. The two-mica granites from the Qiongrang contain relatively high levels of Li and Be, and they are closely related in time-space to the Dahongliutan rare metal pegmative veins, it is speculated that two-mica granites from the Qiongrang possess significant potential for the exploration of hard-rock lithium-beryllium mineralization.