The Mesozoic intracontinental volcanic activity in southern China resulted in the formation of two distinct metallogenic provinces: the eastern tungsten-tin high-temperature metallogenic province and the western gold-antimony-lead-zinc low-temperature metallogenic province, establishing globally significant metallogenic regions. The Nanling metallogenic belt, located in central South China, stands out as one of the world's most densely populated areas with tungsten-tin polymetallic deposits. Throughout different geological periods such as the Caledonian, Indosinian and Yanshanian, Nanling has witnessed the formation of tungsten-tin metallogenic-related granites.During the Indosinian period, the metallogenic activity in the region was notably weaker compared to the Yanshanian period, with research on Indosinian period plutons lagging behind. This article conducts a comparative analysis of the geochemical features between Indosinian tungsten-tin granites and non-ore-bearing granites in Nanling. By integrating previous research findings, it is established that distinguishing between Indosinian tungsten-tin granites and non-ore-bearing granites is achievable through several indicators. These indicators include highly crystallized differentiation, low magnesium iron content, elevated REE+Y, Nb+Ta values, and substantial depletion of Ti and P.