The North Qiangtang—Qamdo Block, located in southern Qinghai, is between the Gondwana and Eurasia, but its tectonic affinity is still controversial. This article discusses Permian tectonic setting of North Qiangtang—Qamdo Block in some aspects. Studies of fusulinids, corals and brachiopods assemblages have indicated that the Permian faunas in southern Qinghai have always been the warm Tethyan type, without coldwater fauna or coexistence of warmwater and coldwater faunas, which shows more similarity with Tethyan and the features of the Yangtzephile plate. That, North Qiangtang—Qamdo Block should belongs to South China Subprovince, Cathaysian—Tethyan Province, Tethyan Realm in palaeobiogeographic affiliation. The geochemical features of the cherts from the northern border of North Qiangtang—Qamdo Block reveal that the depositional environment approached the continent, was formed in intraocean basin between continents on the passive continental margin. That, North Qiangtang—Qamdo basin probably had a continental crust structure. The geochemical features of the Permian sandstones and siltstones suggest that the basin should be a continental crust rift basin formed within extensional setting during Early and Middle Permian, and tectonic setting of provenances was of the island arc type in Late Permian. Volcanic rocks with geochemical characteristics of intraplate alkaline basalts, having highTi and lowTi groups, formed in the epicontinental stretching rift environment (initial rift), while the highTi group shows the features of the Yangtzephile plate. The plot of V1, V2 lead isotopic ratios of volcanic rocks fall into the area of the Yangtze Province. This paper infers that the North Qiangtang—Qamdo Block was a rift basin with continental crust structure during Permian, and always located in the Tethyan Realm, belonging to the PanCathaysian continental group or the Yangtze Plate, and was part of the Tethyan archipelagic ocean system. During Late Paleozoic, North Qiangtang—Qamdo Block have experienced cleavage—expansion—closure tectonic evolution, which evolved from initial rift in Devonian to the early stage of rifting in Carboniferous, and to mature rift stage in Permian. While in Late Early Permian, Panriftzation reached its peak period with strong volcanic activity, and the palaeogeographica pattern of seas between islands was formed. Then, the rift closed and returned in Late Permian, and the unconformity at the top of Wuli Group declared the end of this evolution.