The tectonics-fluids coupling mineralization is one of the core issues in the study of ore deposits. This paper focuses on the research results of tectonics-fluids coupling mineralization in the metallogenic system of non-magma epigenetic hydrothermal deposits. From the two aspects of tectonics action on fluids and fluids action on tectonics, the mechanism of synchronous and mutual influence between tectonics activity and fluids action is summarized. Through the analysis of typical examples, it is believed that the study of tectonics-fluids coupling mineralization should clarify the process of tectonics and fluids mineralization and elucidate the processes of "source-transport-accumulation," process from the coupling relationship of time, space and material, and reveal the mechanism of tectonics activity and fluids mineralization. On this basis. The main direction and development trend of tectonics-fluids coupling mineralization research are put forward. This study is of great significance to enrich the theoretical research on the genesis of hydrothermal deposits and the understanding of metallogenic regularity.