Nanling—Xuancheng area in Anhui province is a newly established ore concentration district in the Middle and Lower Yangtze River Metallogenic Belt (MLYRMB)，and mineral exploration in this area has made important progress in recent years. Based on the results of previous regional geological surveys and the latest regional geophysical exploration and geological exploration of ore deposits，the geological and geochemical characteristics of structures，magmatic rocks and Cu—polymetallic deposits were systematically summarized，the relationship between Mesozoic region tectonism and magmatism， mineralization in the ore concentration district discussed. Research results indicate that the Nanling—Xuancheng ore concentration district is a Meso—Cenozoic continental depression—fault volcano—sedimentary basin controlled by deep faults. There are a serials of NE strike finger- like anticlinoria/thrust nappes overlapping on the basin. The stratigraphic compositions and structural characteristics of the basin- basement are basically same as those of the anticlinoria/thrust nappes, and both of them developped intrusive rocks and related Cu—polymetallic deposits with same age and characteristics. Generally the tectonic—magmatic—metallogenic characteristics of the Nanling—Xuancheng ore concentration district are consistent with other areas in the MLYRMB，indicating that since the Mesozoic era，under the control of the subduction of the Paleo- Pacific plate，the ore concentration district has experienced extreme intracontinental deformation and corresponding multi- stage NW—SE compression and extension. On the other hand，the Nanling—Xuancheng ore concentration district has its peculiarity for the characteristics of structures，intrusive rocks and Cu—polymetallic deposits of it are obviously different from those of the other volcano—sedimentary basins in MLYRMB，reflecting they have some differences in regional tectonic，crustal basement structure and composition，and rvealing that the Nanling—Xuancheng ore concentration district is the typical representative of the MLYRMB composite system of cross construction unit.