This paper provided petrography, LA- ICP- MS zircon U- Pb age, and zircon Hf isotopes of the Middle Jurassic sandstone in Hanshuiquan area, Santanghu Basin, eastern Junggar, analyses the source of clastic materials and its indication for sandstone- type uranium mineralization.Methods: Based on the field work, through the microscopic observation, the LA- ICP- MS zircon U- Pb isotopic chronology, and the LA- ICP- MS zircon Lu—Hf isotopes of malmstone.Result: The detrital zircon ages of the sandstone in the Middle Jurassic Xishanyao Formation are mainly distributed in the Late Paleozoic, and the peak ages of the two samples are 328 Ma and 340 Ma. The detrital zircon εHf(t) ranges from 8.9 to 14.7, and the two- stage model age ranges from 690 to 415 Ma. Detrital zircon ages from the sandstone in the Toutunhe Formation can be divided into three sections: 238~163 Ma, 505~259 Ma and 1950~744 Ma. Detrital zircon εHf(t) is -6.5~12.1, and the two- stage model age is between 1709~575 Ma. Conclusion: The Xishanyao Formation has a single source of material, mainly from the western Karamaili Maiqinwula and Yemaquan regions; the source of the Toutunhe Formation is relatively complex, and in addition to the detrital material from the Karamaili region, it also receives supply from other regions. The sudden change in age characteristics of detrital zircons between the two represents a severe tectonic deformation event in the Middle Jurassic of the East Junggar region. The source characteristics indicate that the uranium content in the Middle Jurassic strata in the Hanshuiquan area is relatively limited, and uranium source is an important factor limiting the mineralization of sandstone type uranium deposits in the area.