Based on the field geological investigation, we study that microthermometry and microlaser Raman microprobe compositions for fluid inclusion from the Qingshuitang Pb—Zn deposit, as well as hydrogen and oxygen isotopic compositions. With reference to previous research data, the physical and chemical conditions of the Qingshuitang Pb—Zn deposit are discussed. The microscopic observation shows that fluid inclusions are erratically developed in different minerals. There are more fluid inclusions occurring in sphalerite and calcite than quartz. It mainly consists of liquidrich twophase inclusions. Microthermometry shows that the homogenization temperatures of sphalerite, quartz, and calcite range from 109℃ to 188℃, 122℃ to 239℃, and 144℃ to 326℃, respectively. Their salinities range from 9.47% to 20.97%, NaCl eq., 0.18% to 16.62%, NaCl eq., and 0.18% to 7.31%, NaCl eq., respectively, of which the homogenization temperatures and salinities of sphalerite are in a narrow range. Microlaser Raman spectroscopy of sphalerite shows the gas phase of the fluid inclusions mainly consists of water vapor. δD(H2O, V-SMOW) of orebearing quartz ranges from -98.9 ‰ to -79.3 ‰ , δ18O(H2O, V-SMOW) ranges from -8.10 ‰ to 0.63 ‰, indicating the oreforming fluid was mainly derived from magmatic hydrothermal water, influenced by the meteoric water. The synthetical analytical results indicate that the Qingshuitang Pb—Zn deposit the evolution of the oreforming fluid is simple and the mixing action is dominant during the mineralization process from the Qingshuitang Pb—Zn deposit.