Exploitation of groundwater resources in Karst area is very difficult and important of the reaserach on hydrogeological,and it directly influence people’s lives and production. Because of deep valleys in Guizhou slope karst area,groundwater is deep and Concentrated runoff in most parts,and it brings great difficulties to exploitation of groundwater resources. The author through the exploration of karst groundwater resources in Guizhou plateau slope zone, Combined with success and failure experience of drilling well upper and lower of reverse fault, points out that the reverse fault as a common form of geological structure, with “dam” role of hydrogeological significance, and the underground aquifer medium of recharge areas can be used as underground reservoir.