The Shuidongling Cu—Zn deposit, Nanzhao County, Henan Province, is situated in the Northern Qinling Orogen. It belongs to the Dongjie—Baishijian—Shuidongling polymetallogenic belt. In this paper, based on field geological investigation, writers discussioned on the metallogenesis of this deposit by employing multiple techniques of fluid inclusions microscopic measurements, analysis of H, O, S, and Pb isotopic compositions as well as K/Ar isotopic age. Analysis of fluid inclusions indicates that the inclusions are primarily liquid enriched vapor liquid inclusions, and their homogenization temperature ranges mainly from 98 ℃ to 354 ℃, while the salinity ranges mainly from 0.1% to 19.99% NaCleq . Laser Raman spectra shows that the main composition of the ore forming fluids is H2O with small amount of CO2. Hydrogen and oxygen isotopic compositions suggest that the fluids for mineralization should mainly have experienced mixing process of magmatic water and meteoric water. δ34SV-CDT of ores ranges in 1.82‰~9.67‰, n(206Pb)/n(204Pb), n(207Pb)/n(204Pb) and n(208Pb)/n(204Pb) vary in 17.341~17.930, 15.490~15.573, and 37.266~37.960, respectively. All the isotopic composition are characterized by changing in narrow ranges and relatively homogeneous. It is indicated that the ore forming materials is mantlely derived. But, there may be a part of the crust material mixed during ore forming processes. K/Ar isotopic ages of biotite and muscovite set respectively for 376.2±3.8 Ma and 350.8±3.5 Ma, equivalent to Late Paleozoic. All the results suggest that the Shuidongling Cu—Zn deposit should belong to transformational type deposits.