Weathering crust is result and record of weathering processes and thus bears invaluable information on paleoclimate, regional tectonism, and landscape evolution of regional and even global significance. Geochronology of weathering crusts provides temporal constraints for establishing the relationships between a variety of global events and continental weathering. 40Ar/39Ar dating of supergene minerals is versatile to directly and precisely time the formation of weathering crust, yielding results required to determine the mechanisms and rates of propagation of weathering fronts, to unravel the climatic and geochemical history implicit in the evolution of continental regolith covers, and to correlate variation in the intensity of regional paleoclimate and mountain uplift. However, problems remain in sampling and isotopic dating of supergene minerals. Moreover, age distribution of weathering profile may be complicated due to episodes of weathering and preferential permeability of zones cutting through by faults. In this regard, systematic sampling and comprehensive geochronological study are imperative to unravel the history of continental weathering. Combination of geochronological results of weathering profiles with independent records such as paleontologic and sedimentary data is required while they are interpreted as paleoclimatic indicators. Laterites or red weathering crusts are widely distributed in South China, which contain appreciable amounts of hollanditegroup minerals that can be dated by the 40Ar/39Ar method. This will allow yielding geochronological framework of weathering and supergene ore enrichment, which is crucial in reconstruction of the Cenozoic paleoclimate and tectonism in South China.