This paper presents a comprehensive study on the mineralization geochemistry and the oreforming mechanisms of the Wangjiazhuang copper deposit in Zouping County, Shandong Province. The homogenization temperature of primary fluid inclusions in the mineralized quartz veins of the Wangjiazhuang copper deposit ranges from 116 ℃ to 566 ℃ with an average value of 289 ℃, while the salinity ranges from 7.2% to 63.2% NaCleq with an average of 21.1% NaCl eq. The Raman spectra indicate that H2O and CO2 are the dominating components in the inclusions. When the homogenization temperature ranges from 240℃ to 440℃, a phenomenon was observed that the vaporrich inclusions, the liquidrich inclusions and the threephase inclusions containing daughter minerals coexisted, meanwhile, vaporrich inclusions homogenized to a single vapor phase and liquidrich ones homogenized to liquid phase, which indicates that the fluid has once been boiling. The first boiling event occurred at about 360 ℃ to 400 ℃, resulting in the formation of the threephase inclusions containing daughter minerals with high temperature and high salinity, the liquidrich inclusions with high temperature and moderate salinity, and the vaporrich inclusions with high temperature and low salinity. The second boiling event, which occurred at about 240 ℃ to 320 ℃, caused the formation of the threephase inclusions containing daughter minerals with medium to high temperature and high salinity, the liquidrich twophase fluid inclusions with medium to high temperature and medium salinity, and the vaporrich twophase fluid inclusions with medium to high temperature and low salinity. The inclusions formed after two boiling events are mainly liquidrich fluid inclusions characterized by low to medium temperature and medium salinity. The δ18OH2O values range from -1.14‰ to 1.79‰ with an average value of 0.94‰, while δD range from -63.70‰ to -56.50‰ with average of -59.80‰. It is deduced that the oreforming fluid was mainly derived from the magmatic fluids and mixed with meteoric water in the late stage. The oremineral are poor in heavy sulfur isotopes and rich in radiogenic lead isotopes. The values of δ34S of oreminerals range from -8.80‰ to -2.20‰ with an average of -6.33‰. The values of n(206Pb)/n(204Pb) range from 18.1684 to 18.3637 with an average of 18.2892. n(207Pb)/n(204Pb) ranges from 15.5546 to 15.6342 with an average of 15.5777. n(208Pb)/n(204Pb) ranges from 38.1286 to 38.4840 with an average of 38.2780. It is indicated that sulfur and lead originated from deeper crust or mantle and were influenced by the mixture from the wall rocks and meteoric water in the late oreforming stage.