Through a review of the research history of the Qinghai-Tibet Plateau uplift and analysis of various dynamic models of the uplift, a dynamic model of the Qinghai-Tibet Plateau uplift, deep thermal uplift spreading, is suggested on the basis of the intensive inhomogeneity of the lithosphere fabrics and structural geomorphologic pattern of tridivision and symmetry. The uplift of the Qinghai-Tibet Plateau is a synthetic result of the bidirectional inhomogeneous subduction of the India block and Tarim-Alxa block and deep thermal-uplift spreading of the Qinghai-Tibet hinterland. Subduction is an important mechanism of the uplift, and deep thermal-uplift spreading is the direct cause.