Based on the geoscience transects from Yadong to Golmud and from Golmud to Ejin, and new geophysical survey data, the paper discusses thirty problems of the lithospheric structure and dynamics in the Qinghai-Xizang (Tibet) Plateau, involving formation, structure and deformation of the plateau, material flow, history of the rise of the plateau, and geodynamics. Some of them concern the geoscience frontier of the Qinghai-Xizang Plateau. The author hopes to deepen the study of the continental dynamics of the Qinghai-Xizang Plateau through a discussion of these problems.