The Hesar pluton in the northern Urumieh–Dokhtar magmatic arc hosts numerous mafic-microgranular enclaves (MMEs). Whole rock geochemistry, mineral chemistry, zircon U-Pb and Sr-Nd isotopes were measured. It is suggested that the rocks are metaluminous (A/CNK = 1.32–1.45), subduction-related I-type calc-alkaline gabbro to diorite with similar mineral assemblages and geochemical signatures. The host rocks yielded an U-Pb crystallization age of 37.3 ± 0.4 Ma for gabbro-diorite. MMEs have relatively low SiO2 contents (52.9–56.6 wt%) and high Mg# (49.8–58.7), probably reflecting a mantle-derived origin. Chondrite- and mantle-normalized trace element patterns are characterized by LREE and LILE enrichment, HREE and HFSE depletion with slight negative Eu anomalies (Eu/Eu* = 0.86–1.03). The host rocks yield (87Sr/86Sr)i ratios of 0.70492–0.70510, positive εNd(t) values of +1.55–+2.06 and TDM2 of 707–736 Ma, which is consistent with the associated mafic microgranular enclaves ((87Sr/86Sr)i = 0.705014, εNd(t) = +1.75, TDM2 = 729 Ma). All data suggest magma-mixing for enclave and host rock formation, showing a complete equilibration between mixed-mafic and felsic magmas, followed by rapid diffusion. The TDM1(Nd) and TDM2(Nd) model ages and U-Pb dating indicate that the host pluton was produced by partial melting of the lower continental crust and subsequent mixing with injected lithospheric mantle-derived magmas in a pre-collisional setting of Arabian–Eurasian plates. Clinopyroxene composition indicates a crystallization temperature of ~1000°C and a depth of ~9 km.