Land subsidence is a severe hazard threatening Tanggu, a flat lowland area, and evidences of land subsidence can be seen throughout the city. A new reasonable GPS network was set up in this area from 2008 to 2010. The monitoring data show that land subsidence was serious and two main subsidence cones were obviously formed in the region. One emerged at Hujiayuan, with the maximum rate reaching 60 mm/a, and the influence region enlarged prominently from 2005 to 2010. The other one occurred at Kaifaqu, which became obvious only after 2005, and it showed a decreasing tendency with time. To analyze the causes of ground settlement, a correlation between groundwater withdrawal and land subsidence was firstly made. The results confirmed that over-exploitation of groundwater was the major cause for the severe settlement in Hujiayuan. Meanwhile, the subsidence of Kaifaqu was also related to groundwater withdrawal before 2005. However, the relationship became unconspicuous after 2005. To find the cause of this abnormity, a three-dimensional finite element numerical model, coupled with groundwater flow and subsidence, was built. The simulation results indicate that the subsidence induced by high-rise buildings is serious, but the affected range is limited and it also shows a decreasing trend with time, corresponding to the subsidence characteristics at Kaifaqu. Therefore, more attention should be paid to this hazard induced by engineering construction besides groundwater withdrawal, as more high-rise buildings are under construction in Tanggu.