Previous studies have paid limited attention to both the intrinsic deformation mechanisms of the evaporite-bearing sequences within the Cambrian Gaotai Formation in eastern Sichuan and the relationship between sedimentary facies distribution and salt tectonic deformation. Consequently, the location of grain shoals along the margins of salt sags within the Gaotai Formation cannot be constrained, which has hindered petroleum exploration targeting this formation. To address these issues, this study integrates structural interpretation of seismic reflection profiles from the north-central part of eastern Sichuan, numerical simulation of structural deformation, fold uplift age data, drilling data, and thickness information of the overlying Xixiangchi Formation. This multi-faceted approach was used to investigate the development mechanisms of Gaotai Formation salt structures, the response relationship between salt tectonic deformation and original deposition, and to summarize the characteristics of favorable zones for grain shoal facies along the Gaotai Formation salt depression margins. The results indicate that: (1) The synclinal zone corresponds to the marginal zone of the saline depression during the depositional period of the Gaotai Formation, while the anticlinal area matches either the center of the saline depression or the facies transition zone between the saline depression and its margin. (2) The primary mechanisms for salt structure development in the salt depression areas are contraction and buoyancy forces. (3) The incongruous folds beneath the Gaotai Formation within the synclinal areas represent favorable zones for hydrocarbon accumulation.