The west section of Bonan low uplift in the Bohai Bay Basin has been found to have great characteristics of medium-deep buried-hill type oil and gas trap in recent exploration work, and internally discovered the Bozhong 26-6 large-scale oil and gas reservoir. Discussions on the formation and evolution of buried-hills, the development sedimentary systems, and the mechanisms of oil and gas generation, storage and migration often require tectonic analysis and tectonic geomorphological restoration work. Therefore, to reveal the complete tectonic deformation and geomorphic evolution of the west section of Bonan low uplift, and to provide theoretical support for oil and gas exploration, this paper, based on the reflection seismic and drilling data in the study area, detailed the strata distribution and tectonic deformation characteristics during Mesozoic-Cenozoic, and used Move software to conduct two and three dimensional tectonic restoration, accurately restoring the geomorphological features during the major periods of tectonic activity. Results reveal that: (1) During the early Mesozoic (from the Indosinian to the early Yanshanian), under the strong compressional orogeny transitioning from a near S-N to NE direction, the study area developed a numerous near E-W and NE directed thrusts, as well as several near S-N strike slip faults. The region experienced intensive uplift, with the overall lack of the Jurassic sedimentation and extensive erosion of the Paleozoic strata. The Precambrian basement was exposed and flattened, presenting a large-scale flattened mountain landform. (2) During the late Mesozoic (from middle to late Yanshanian), under a strong NW-SE directed extensional environment, the reverse faults in the Huanghekou Depression on the south side of the uplift experienced intense negative inversion activity. This allowed the depression to receive a large amount of Cretaceous volcaniclastic and muddy-sandy sediments. The west section of Bonan low uplift and part of the Bozhong Depression on the north side still exhibit uplifted landforms and serve as sediment source areas. (3) During the early Cenozoic (from early to middle Himalayan), under the strong NW-SE directed extensional and rift environment, the study area experienced near S-N directed bidirectional detachment activity. The Huanghekou Depression continued to experience southward faulting, forming a basket-shaped and half-graben shaped structure. The strata in the Bozhong Depression underwent northward faulting and detachment. The west section of Bonan low uplift was affected by transtensional detachment, presenting a geomorphic feature of “high and narrow in the west, low and wide in the east”, ultimately forming the current tectonic pattern of “two depressions with one uplift”, providing space for the deposition of Cenozoic Shahejie Formation source rocks and Dongying Formation cap rocks.