The Fe deposit in the Qihe－Yucheng area is a newly discovered skarn－type iron－rich deposit in the ultra－deep cover area in Luxi area of Shandong Province, which is closely related to the Early Cretaceous dioritic magmatism, but the age of mineralization has not been well qualified. In this paper, LA-ICP-MS U-Pb isotope dating, major and trace elements analysis, hydrogen－oxygen stable isotope analysis and mineral inclusions analysis were carried out on garnet from the Pandian skarn－type Fe deposit. Garnet is mainly composed of andradite ( And = 55.55 % ~ 74.24 % ) and grossular ( Gro = 22.16 % ~ 40.05 % ), belonging to grossular－andradite series. The garnet Tera－Wasserburg diagram of the two skarn samples shows that the lower intersection ages are 122.8 ± 3.4 Ma and 123.7 ± 9 Ma, belonging to the Early Cretaceous. The rare earth compositions generally show a left－dipping type with light rare earth elements loss and heavy rare earth elements relative enrichment, with obvious Eu positive anomaliy. The inclusions are mainly molten inclusions, containing iron components such as hematite and iron complexes. The value of δDV－SMOW of inclusions is －69.50‰~－88.30‰, and the value of δ¹⁸OH2O is 8.43‰~12.21‰, which belongs to magmatic water. Comprehensive analysis suggests that the Pandian Fe deposit in the Qihe－Yucheng area is the product of the peak period of thinning and destruction of the North China Craton in the early Early Cretaceous. The ore－forming fluid is derived from the iron－rich high－temperature magmatic hydrothermal, in which the slightly acidic neutral and oxidizing environment provided conditions for the unloading and mineralization of Fe.