The Au-Cu polymetallic deposits represented by the Qibaoshan ore-concentration area of Wulian county is developed in the Southern Margin of Jiaolai Basin, three typical deposits are developed, namely, Jinxiantou Au-Cu deposit, Diaoyutai pyrite deposit and Qibaoshan Pb-Zn polymetallic deposit. In order to further elucidate the genetic relationship between ore deposits, improve the study of ore-forming system in ore concentration area, and establish the ore-forming model of ore deposits, the main sulfides in the ore deposit were tested and analyzed in situ for sulfur isotopes and trace elements of pyrite.. The sulfides in the Qibaoshan ore concentration area has a relatively concentrated sulfur isotope peak distribution range (0‰ ~ 6‰), which comes from the same or similar deep magmatic system.. The Cu, Zn, As, Se, Ag, Sb, Pb and Bi in pyrite show relatively regular changes from Jinxiantou Au-Cu deposit to Diaoyutai pyrite and then to Qibaoshan Ag-Pb-Zn polymetallic deposit, The distribution characteristics of elements show that the ore-forming fluid as a whole presents an evolution process from magmatic hydrothermal to mixed hydrothermal. Comprehensive analysis shows that the deposits in Qibaoshan ore collection area are closely related in time and space. The deposits are the products of the same geological and tectonic environment and different parts of rock construction, which together constitute the porphyry-epithermal Au-Cu-Pb-Zn-Ag polymetallic metallogenic system in Qibaoshan area.