The Mesozoic granitic pegmatites of the West Kunlun- Karakoram orogenic belt are remarkably well- developed, mainly distributed within the Karakoram orogenic belt. This belt, located south of the Maza Kangxiwa suture zone, stretches for an impressive 600 km from Muji Taxkorgan in the west to Dahongliutan in the east, forming a significant Karakoram rare metal mineralization belt. This study presents a comprehensive and systematic analysis of 37 rare metal deposits hosted within the West Kunlun- Karakoram orogenic belt. The Karakoram orogenic belt exhibits a striking spatial pattern, with beryllium deposits dominating the west and lithium deposits concentrated in the east. The age of rare metal mineralization in this region is primarily clustered between 213 and 206 Ma. The Karakoram orogenic belt can be subdivided into two distinct sub- belts: the Muji- Taxkorgan rare metal mineralization sub- belt and the Saitura- Dahongliutan rare metal mineralization sub- belt. From west to east, four rare metal mineralization concentration areas can be identified: Muji- Bolunkou, Tashkurgan- Tatulugou, Kangxiwa, and Dahongliutan- Bailongshan. This research suggests that the next stage of mineral exploration in the western section of the West Kunlun- Karakoram region can be focused on the Xihexiu South lithium beryllium exploration section, the Aranbaotai beryllium exploration section, and the Mujixi lithium beryllium exploration section.