The Ando microland massif in Tibet, as a microland massif within the Bangong Lake-Nujiang River suture zone, has recorded multiple phases of tectonothermal events since the Neoproterozoic-Mesozoic era, and is an ideal object for the study of the genesis of the deep-melt-granitoids. In order to reveal the characteristics of the fluid/melt activities during the subduction-folding process of the oceanic plate, a comprehensive study was carried out herein, combining the whole-rock geochemistry, systematic petrology, zircon internal structure, zircon U-Pb ages, and Lu-Hf isotopes. A comprehensive study was carried out. Petrographic observations show that the mixed gneiss retains key field macro- and microscopic evidence of deep melting: (1) light and dark bodies are interbedded in a laminated distribution, accompanied by weak fold deformation; (2) there are assemblages of fine grains at the boundaries of quartz and potash feldspar, and irregular crystallization of potash feldspars from edge to middle; (3) plagioclase feldspar and potash feldspar boundaries show highly acicular, elongate, or wedge-shaped quartz and feldspar grains, with "bead" structures along the quartz and feldspar grain boundaries. The cathodoluminescence images and zircon U-Pb dating results show that the zircons in the mixed-rock gneisses have a distinct core-rim structure, with a distinctive oscillatory ring in the zircon cores, which gives a magma crystallization age of ~510 Ma, and narrow metamorphic or deep-melting rims in the rims. The zircon in the light-colored body has obvious core-rim structure, and the CL image shows that the zircon core is highly luminous with oscillatory ring band, which may be inherited magmatic zircon, and the zircon rims show deep melting features such as weakly fractional bands of grayish to dark color or no fractional bands, and the age of the core is ~510-470 Ma representing the age of protolithic crystallization, and the rims have an age of ~184 Ma indicating the age of melt crystallization. The zircons of the granodiorite have typical magmatic zircon characteristics, with a magmatic crystallization age of ~180 Ma, which agrees with the age of the light-colored body within the error range. The εHf(184) values of deep-melting diagenetic zircons in the light-colored body range from -5.0 to -3.3, while those of granodiorite magmatic zircons range from -10.97 to -5.21. Whole-rock geochemical analyses indicate that Fe2O3T, MgO, TiO2, CaO, and REEs are almost completely retained in the dark-colored body, while a large number of LILEs (Rb, Sr, K, Ba ) are to the light-colored body. The light-colored body is divided into Type I light-colored body and Type II light-colored body according to the whole-rock REE characteristics and whether it carries residual hornblende, in which Type I light-colored body has higher total rare earth content and negative Eu anomaly, while Type II light-colored body has lower total rare earth content and positive Eu anomaly; the trend of the distribution of rare earths (REEs) of granodiorite eclogites is consistent with that of Type I light-colored with an enrichment of the large ionic proximate elements (Rb, Ba, and Th) and a Negative Eu anomalies; the synthesis of the existing regional data and the field relationship, microstructure, chronology and geochemical results obtained in this paper indicate that the black cloud plagioclase gneisses of the Ando microterrane occurred in the subduction and folding stage of the hydrous partial melting involving black mica, and that the type I light-colored bodies in the mixed rocks formed the contemporaneous granodiorite bodies through large-scale convergence, migratory evolution and encroachment.