Abstract: The Shujiadian intrusion is between the Tongling fault uplift and the Fanchang fault basin in the middle of the lower Yangtze River. The rock types of this intrusion include pyroxene diorite, quartz diorite porphyry, granodiorite porphyry, diorite and diorite porphyry. Based on LA-ICPMS U-Pb dating of zircons and geochemical compositions and Pb isotope of pyroxene diorite – the important rock of Shujiadian intrusion, this paper studied the geochronology, the source and evolution of magmas, and the tectonic setting of the Shujiadian intrusion. The results indicated that, the ages of Shujiadian intrusion is 139.2±2.1Ma（MSWD=2.3, n=12), belonging to Tongling area, not Fanchang volcanic basin. Pyroxene diorite is high potassium serirs. The Shujiadian intrusion might be derived from the metasomatic enriched mantle (EMΠ). There were a series of crystal fractionation of minerals such as apatite, amphibole, pyroxene and plagioclase, which also affected by the assimlation of crust materials during the evolution of the magmas. The intrusion formed in a compressional regime.