Salt structure is a focus issue of tectonics and petroleum geology research, and is closely related to hydrocarbon accumulation. Thick salt layers are here in Kungurian Formation of the Lower Permian in the Pre- Caspian Basin, and salt- related structures here include salt diapir, salt pillow, salt roller, salt margin depression, salt weld and turtle structure, thus the deformation mechanism is very complicated. However, since the main control factors and dynamic mechanism of the macroscopic deformation of the salt structure, and the influence of the underlying stratum micro- geomorphology on the structural deformation of the overlying salt layers are unclear, insights of the salt structures on hydrocarbon accumulation is restricted. Based on the seismic data of the eastern margin of the Pre- Caspian Basin and the distribution characteristics of the strata, the stratigraphic geological model of the eastern margin of the basin is established, and the physical simulation experiment models are designed accordingly. By physical simulation experiments, the process of salt structure deformation is studied, and the relationship between salt structure deformation mechanism and underlying stratum geomorphology is concluded. Via the construction of physical simulation experiments, industrial CT dynamic monitoring andscanning, and three- dimensional reconstruction techniques, the visualization and dynamization of the research process are realized. Results show that:①〖BP(〗=1\*GB3〖BP)〗The main driving force for the formation of salt structure is the compressive; The structural deformation force of the Pre- Caspian Basin mainly comes from the eastern Ural orogeny; In addition, the detachment of the salt layer will also affect the deformation of the strata, forming inter- layer folds and causing faultsbetween and above salt layers.②〖BP(〗=2\*GB3〖BP)〗From the Late Permian to the Triassic, the uneven deposition of debriscaused bythe differential load to the basin from the Ural fold belt in the eastern part of the Pre- Caspian Basin is also a main driving force for formation of fault structure.These insights have guidingresearch on salt- related structures and oil and gas exploration in the Pre- Caspian Basin.