As the main source of water supply for urban district of Suzhou, northern Anhui, middle—deep confined groundwater plays an important role in social and economic development. However, groundwater pollution pressure became increasingly intense with the acceleration of urbanization. Vulnerability of middle—deep confined groundwater in urban district of Suhzou was evaluated to guide middle—deep confined groundwater exploitation and groundwater protection. Methods: Based on the geological and hydrogeological data collected in urban district of Suzhou, combined with the DRASTIC model principle, groundwater level depression(D), aquifer hydraulic permeability(P), quiclude thickness(T), shallow groundwater quality(Q), water- head(H) and permeability coefficient of aquiclude(C) were taken as evaluation indexes to establish DPTQHC model which was suitable for vulnerability assessment of middle—deep confined groundwater. Results: The distribution area of moderate groundwater vulnerability subzone is the most widely, followed by relatively low vulnerability subzone, relatively high vulnerability subzone, high vulnerability subzone and low vulnerability subzone. The results of the evaluation are in good agreement with the measured groundwater quality in the area. Conclusions: Compared to DRASTIC method which is used to evaluate shallow groundwater vulnerability, PHBATQ model is more suitbale for assessment of middle—deep confined groundwater vulnerability. The evaluation results can provide scientific basis for groundwater resources and environmental protection.