Nanpanjiang—Youjiang metallogenic area is one of the most important gold resources producing areas in China, where Carlin type gold deposits are concentrated in south China. Based on the sedimentary system, formation system, rock system, tectonic system, geochronology system, material system, positioning system dynamic system expand the connotation of tectonic erosion variation, to establish the discriminant index, expounded that they can occur not only between unconformities, but also between rocks with large differences in permeability, build the card cover type of gold deposits in multi- level tectonic slippage metallogenic system of southern China, and a comprehensive model for regional prospecting prediction of Carlin type gold deposit in Guizhou province is established. Based on the constructed metallogenic system and prediction model, the regional metallogenic prediction was carried out, the prospecting target area was delineated, the prospecting practice under the guidance of theory was carried out, and the historic breakthrough of Guizhou Carlin- type gold deposit was realized.