Oil source faults connect the underlying source rocks and overlying reservoirs in the petroliferous basin, and they are active in the hydrocarbon accumulation period. They are not only the transport channel of oil and gas migration, but also the barrier of oil and gas accumulation, which play a very important role in the migration and accumulation of oil and gas. However, it is not certain that there are oil and gas reservoirs near the source fault. Accurately predicting the favorable position of oil and gas accumulation is the key of oil and gas exploration near the oil source fault in the lower source and upper reservoir in petroliferous basin. Methods: In order to study the rules of oil and gas accumulation near the oil—gas source faults in the lower source and upper reservoir oil—gas basin, on the basis of the study on the mechanism and the favorable parts of oil—gas migration and accumulation due to oil source fault conduction and shielding, the favorable parts of oil and gas transmission are determined by defining the development parts of the associated fractures of oil—gas source faults and the distribution areas of oil—gas reservoir sand bodies; and the favorable position of oil and gas shielding of oil source fault is determined by defining the lateral sealing position and distribution area of reservoir sand body of oil source fault and distribution area of reservoir sand body. The location and distribution area of reservoir sand body are determined, and the favorable position of oil and gas shielding of oil source fault is determined. A set of prediction method for the favorable position of oil and gas migration and accumulation by oil source fault is established by combining the two methods, and it is applied to the prediction of the favorable position of oil and gas migration and shielding configuration in the Es13Submember of Banqiao fault in Qikou Sag of Bohai Bay Basin. Results: The results show that favorable accumulating position of oil and gas migration and shielding configuration in the Es13Submember of Banqiao fault is mainly distributed in the middle of northeast and a small amount in the east of southwest, which is conducive to the oil and gas generated in the lower Es3source rock migrating and accumulating in the Es13Submember. Conclusions: At present, the oil and gas discovery in the Es13Submember near Banqiao fault are mainly distributed in the middle of northeast and a small amount in the east of southwest, which indicates that this method is feasible to predict the favorable position of oil and gas accumulation in oil source fault migration and occlusion configuration.