Objectives: This work aims to investigate a probable Cretaceous denudation—cooling process in the inner part of Xizang(Tibetan) Plateau before the Cenozoic India—Eurasia collision.Methods: We carried out a preliminary zircon (U—Th)/He study based on samples from 3 boreholes in the central Xizang Plateau and compiled a number of low temperature thermochronological age data, including zircon (U—Th)/He, apatite fission track and (U—Th)/He ages, throughout the Qiangtang Block, Lhasa Block, and Himalaya Block, by analyzing their temporospatial distributions and potential links with some specific geological events and tectonic background, to discuss an early denudation—cooling process in the Qiangtang Block.Results: Zircons of 9 samples from 3 boreholes in the Qiangtang Block give (U—Th)/He ages of from 127 to 114 Ma in the well QD- 17 , from 92 to 64 Ma in the well QZ- 16, and 88±5 Ma in the well QK- 1, respectively. These ages are weakly correlated with their altitudes and show a trend of decreasing from the top down and from west to east. Conclusions: The zircon (U—Th)/He age pattern from boreholes indicates an obvious denudation—cooling process during Cretaceous in the Qiangtang Block. The statistical result of thermochronological ages show a distribution pattern that the inner part of Xizang Plateau holds older ages from Cretaceous to Early Eocene, while the marginal part of Xizang Plateau has much younger ages from Late Miocene to Pleistocene. They together indicate an early denudation—cooling process during Cretaceous in the inner part of Xizang Plateau. This earlier cooling before the widely known Cenozoic one triggered by India—Eurasia collision can be linked to an Early Cretaceous tectonic unconformity from the northern Lhasa Block to the north front of Xizang Plateau and is quite probably the consequence of the closure of the Meso- Tethys Ocean and following collision of the Lhasa Block and the Qiangtang Block.