Objectives：The Upper Cretaceous—Paleogene sections of Liujia area in the south of Sichuan Basin and of Yijiu area in the north of Chuxiong Basin have been studied, which purpose is to further understand the provenance change and tectonic activities in the western margin of the Upper Yangtze basin. Methods: We carried out some researches of the Upper Creteaceous—Paleogene sections by sedimentary structure, traditional heavy mineral analysis, and the geochemistry of rutile trace elements in the western margin of the Upper Yangtze basin. Results: The results show that：①In late Late Cretaceous, the medium—acid magmatic rock index (ATi) and the low—middle grade metamorphic rock index (GZi) increased in Liujia section, and the medium—acid magmatic rock index (ATi) increased in Yijiu section. Liujia section is rich in garnet mineral, which is the key difference from Yijiu section. ②The types of rutile mother rocks in Liujia section and Yijiu section are mainly argillaceous metamorphic rocks, with amphibolite facies and eclogite facies as the main types. In the late Late Cretaceous, the granulite facies in Liujia section reached the maximum value of 39%, and the minimum value of granulite facies in Yijiu section reached 13%. The variation trend of granulite facies in the west margin of the Upper Yangtze basin is a manifestation of the provenance difference. Conclusions: The Late Cretaceous provenance changes in the western margin of the upper Yangtze basin revealed that a large- scale rapid uplift and denudation events occurred in the Songpan—Ganzi Fold Belt and Longmenshan Structural Belt in the late Late Cretaceous.