The purpose of this paper is to discuss the integrated mitigation strategies for catastrophic landslide induced by the extreme weather events, to enhance the capability of science, technology and management of initiative landslide prevention and mitigation, which as activities undertaken to strengthen response capacities to landslide under the global change condition in China. Based on the presentation and discussion of the participants of workshop on Global catastrophic event and mitigation strategy for major landslide, combination with the major landslide events in recent years, this paper will analyze the impact of neotectonics movement and seismic activity, climate change, population growth and urbanization process, try to explore why there were so many and frequently landslide occurred in 2010 and make a macro judgment of the overall situation of landslide prevention in the future. Comprehensive analysis preliminary revealed that: ① In recent years, the global tectonic movement and seismic activity were into a new relative active period, China is located at the intersection area of the Eurasian seismic belt and the circumPacific seismic belt, where is the strongest response area of current tectonic activity and earthquake. Especially, due to the Indian plate intense activity, the margin of the Tibetan Plateau region trend to frequently seismic activity, enhanced intensity of fault activity and hence, more frequently landslide occurrence by interaction of internal and external motivation in the recent future. ② With the impact of global climate change, extreme and abnormal patterns weather conditions make the mechanism of landslide tend to diverse and complex, due to China is the largest convergence of continental climate and oceanic climate zone, also the wariest climate difference region caused by height difference of landscape, especially in 2010, a long time drought followed with concentration highintensity and long duration rainfall in the raining season, local strong storm caused largescale landslide, flooding and debris flow, particularly in the margin of the Tibetan Plateau; ③Population growth, urbanization, construction and economic activity are important factors for landslide risk which should not to be ignored. Large scale urban developments with high intensity engineering construction, economical activities have been gradually transferring into western China, where ecological and geological environment is relatively fragile. The rapid increasing population density in urban area, especially in mountainous city or town, which relatively lack of independent capacity of landslide prevention and mitigation, directly caused increasing casualties and properties loss. In order to strengthen adaptive response capacities to landslide under the global change situation in China, this paper will present 7 comprehensive mitigation proposals for discussion which learning from international natural disaster reduction and risk management experience, and try to promote the government departments, professional and technical staff involved in integrated mitigation communication and discussion, to promote landslide prevention and mitigation technology and strategies applied in practice, which may contribute to comprehensive landslide mitigation strategies for global change in China.