Abnormal high pressure is distributed in a E-W-stretching zone in the Kuqa depression. The formation pressure coefficient is above 2. 0 in the middle part of the Kelasu - Dongqiu - Dina structural zone, and it decreases northwards and southwards from the centre. The distribution of abnormal high pressure is relative to Eogene gypsolith and salt layers. Huge gypsolith and salt layers are the important condition for the formation of abnormal high pressure. Tectonic compression at the late stage of the Himalayan Orogeny is the main factor of the formation of the abnormal high pressure in the Kuqa depression. The formation pressure and residual formation pressure have good relations with the maximum tectonic principal stress. The influence of tectonic uplift on the formation of the abnormal high pressure is relatively small. Abnormal high pressure has a very important effect on the formation and preservation of oil and gas reservoirs and is a necessary condition for formine larse oil and gas reservoirs in the Kuqa depression.