Recent achievements in obtaining information of the evolution of oceanic Nd isotopic composition in the Cenozoic and its environmental significance are summarized. Variations in the circulation between the Pacific and Atlantic and in Nd isotopic composition corresponded to the closing of the Panama seaway 5 - 3 Ma ago. However, the cause for the little variation in Nd isotopic compositon in the Indian Ocean in the same period is not clear and needs further work to reveal.