Massive sulphide deposits (MSD) in South China are believed to be formedoriginally by submarine exhalative-sedimentary processes and then transformedand superimposed by late-stage tectonic and hydrothermal processes. There areseveral epochs for the formation of MSD, particularly those of the Mid-Late Pro-terozoic, Devonian, Carboniferous and Late Jurassic to Early Cretaceous. Metal-logenic space are strongly controlled by tectonic extension, magmatic culminationand paleogeographic and lithofacies transition. The MSD in South China are distributed in belts and clustered in separatedareas. Five metallogenic belts are delineated in South China. They ate, all locaiednear boundaries between terranes or other tectonic units; appear to be in closespatial and genetic relation to mantle bulge beneath the crust; and occur inelongated basins. MSD are usually densely distributed around some particularcenters in specific metallogenic belt to form deposit clusters. Deposit clusters arethought to be controlled by those factors where are intersections of large basementfaults, intense magmatism, synsedimentary depressions and so forth. Metallogenesis of MSD in South China is characterised by inheritance of pol-ycyclic deposits. MSD of various ages exist in the same metallogenic belt. Forinstance, MSD in the Lower Yangtze retion are of four metallogenic epches. It is most probobly the transformation and superimposition of MSD by late-stage intrusions that caused the coexistence of these deposits with skarn-and/orporphyry-type deposits in a small areal. Criteria for ore prospecting in South China are proposed.