Inkisi Formation is one of the earliest sedimentary strata in the southwest margin of Congo Basin. Its lithology is mainly a set of purplish red, reddish-brown fine-grained, fine-medium-grained arkose and gray-grained arkose. Detrital zircon dating and petrogeochemistry of Inkisi Formation are carried out to explore its depositional age, material source, sedimentary environment and tectonic setting, providing scientific basis for the study of the evolution of the Congo Basin. The results show that the 206Pb/238U age of detrital zircon is mainly concentrated in the three peak age ranges of 2350-1900Ma, 1150Ma-850Ma and 850Ma-500Ma. The peak age of the youngest zircon is 531±9Ma. The upper limit of depositional age of Inkisi Formation in this area is the Early Cambrian. The geochemical characteristics of the sandstone of Inkisi Formation show that the provenance has the characteristics of near-source transport of felsic provenance, and the water in the sedimentary period was an open freshwater environment of continental facies. Based on the age spectrum of detrital zircon, source identification of major trace elements and structure identification diagram, the results show that the West Congo tectonic zone is the main provenance zone, followed by the Lufilian tectonic zone and Angola shield. The tectonic environment of its provenance area is mainly active continental margin and passive continental margin tectonic environment background.