The Tianqiao Pb—Zn ore deposit, Hezhang County, is located in the southwest of the Yangtze craton, the center of the Northwestern Guizhou Pb—Zn metallogenic province, and is a representative of the Pb—Zn ore deposits in this area, where more than 96 ore (deposits) spots have been found. There are three mainly ore bodies in this deposit, whose Pb+Zn reserves are more than 0.2 Mt. This paper analyzes the sulfur and lead isotopic compositions and REE contents of these orebodies. The data show that the ore minerals in these orebodies are enriched in heavy sulfur, with δ34SV-CDT values concentrated between 8.4 ‰ and 14.4‰, and they have the feature of δ34Spy>δ34Ssp>δ34Sga, which indicate the sulfur isotope in oreforming fluids has attained equilibrium. The δ34SV-CDT values of the deposits are similar to that of the sulfates from carbonate strata of different ages in the orefield (15‰), which suggests that the sulfur in the oreforming fluids should be derived from the thermochemical sulfate reduction of sulfates from the sedimentary strata. The n(206Pb)/n(204Pb), n(207Pb)/n(204Pb) and n(208Pb)/n(204Pb) values of the minerals are range from 18481 to 18544(average 18516), from 15.708 to 15.763(average 15728) and from 38.875 to 39.057(average 38.945), respectively, which mean the Pb isotope ratios are normal and similar to that of the host carbonate rocks of different ages strata, indicating that these rocks may provided metals together to the oreforming metals. All samples have the low contents of ΣREE (<3×10-6), and negative Eu anomaly(0.13～0.88). On the chondritenormalized REE patterns, the characteristic of sulfides are accord with the patterns of ores, altered dolostone rock, strata and the pyrite form C1d(the Datang Fm.), which indicate that the oreforming fluids maybe come from polycomponenet system, the different chronostratigraphic units maybe make an important contribution together, this accord with the S and Pb isotopes' result, that is the oreforming fluids and oreforming metals are polysources.