South China is one of the most important regions for Mesozoic W, Sn, Mo, Bi, Cu, Pb—Zn and Au in China, even over the world. We recognized there are three mineralized pulses in Mesozoic, i.e. Late Triassic (230~210 Ma), Mid—Late Jurassic (170~150 Ma), and Early—Middle Cretaceous (134~80 Ma) in South China, which are corresponding to postcollision of convergence of North China craton and South China massif along the Dabie—Sulu suture at Triassic age,backarc magmatic belts of continent margin triggered by subduction of the PaleoPacific plate, and regional lithospheric extensional regime. Furthermore, based on the association of mineral deposits, oreforming metal zoning and orecontrol structures and host rocks， the four mineral models are proposed in this paper. They are porphyry—skarn polymetallic copper deposit model at 170~160 Ma，graniterelated tungsten—tin deposit model at 160~150 Ma; epithermal Au—Ag—Cu and porphyry tin mineral deposit model and graniterelated tin mineral deposit model at age of 134~80 Ma. These models can be applied to further prospecting in South China and the other similar tectonic settings.