There has been no substantial breakthrough in uranium prospecting in Bayingobi Basin for many years, it is necessary to use new techniques and methods to get new understandings, and provide clues for uranium exploration in this area. Methods: Based on WorldView- 3 (16 bands) remote sensing data, anomaly information of iron staining, Al—OH, Mg—OH and carbonate was extracted using principal components analysis, combined with field verification, ground gamma- ray spectrum measurement, thin sections observation and geochemistry analysis to further identify the alteration information types and distribution in Benbatu area of Bayingobi Basin. Resutls: The extracted iron staining, Al—OH, Mg—OH and carbonate information mainly distributes in the lower member of the Bayingobi Formation in the north of the study area, the granitic rock mass of Tukemu uplift in the south and the target stratum (the upper member of the Bayingobi Formation) at the edge of the depression. Comprehensive analysis indicates that iron staining and carbonate in the upper member of the Bayingobi Formation are most closely related to uranium mineralization. Furthermore, from the analysis of WV- 3 image, the target stratum was seriously deformed and damaged in the northwest wing of NE syncline in the study area, which is not conducive to the formation of sandstone- type uranium deposits. The hinge zone and southeast flank of the syncline are stable, which is favorable for groundwater and hydrothermal migration, and it is also beneficial to uranium mineralization. Conclusions: Based on the distribution of anomaly information extracted by the WV- 3, Combined with geology, geochemistry, and the analysis of WV- 3 images, it was considered that the hinge zone and southeast flank of the syncline in the northeast of Xinniwusu depression are favorable sections for uranium exploration in the next step. This study shows that the WV- 3 remote sensing data can be well applied to sedimentary rock areas, and play an important role in exploring sandstone- type uranium deposits.