Pusangguo is the only cobalt- rich skarn copper polymetallic deposit found in the Gangdese metallogenic belt in Xizang (Tibet) in recent years. It has high grade of copper, lead and zinc and great development value. Biotite granodiorite and diorite porphyrite intermediate acid intrusive rocks are exposed in this mining area. These intrusions are formed in Miocene, but its ore bearing property has not been identified. Whether there is porphyry copper mineralization potential is worthy of further discussion and research. Methods: In this paper, LA- ICP- MS analysis technology is mainly used for systematic in- situ trace element analysis of zircon in biotite granodiorite and diorite porphyrite. Results: The calculation results of zircon initial saturation temperature and zircon crystallization temperature show that the zircon initial saturation temperature range of biotite granodiorite is 633~645℃, and the zircon crystallization temperature is 658~817℃. The initial saturation temperature of zircon in diorite porphyrite is 549~626℃, the crystallization temperature of zircon Ti is 640~772℃, and the initial saturation temperature of zircon is lower than the crystallization temperature of tZr-Ti, which comprehensively indicates that there is multi- stage magmatic melt recharge during the formation of medium—acid magma. The characteristics of zircon n(Ce4+)/n(Ce3+), EuN/Eu*N, trace element Dy/Yb, (Ce/Nd)/Y ratio and oxygen fugacity (ΔFMQ) show that biotite granodiorite has a higher oxygen fugacity range (ΔFMQ +0. 44 ~ ΔFMQ+3. 86) and relatively high water content than diorite porphyrite. Conclusions: The biotite granodiorite is more conducive to the further enrichment and mineralization of copper, sulfur and other ore- forming elements in the magma of pusangguo mining area, and medium—large- scale metal deposits may be developed in the mining area. However, the possibility of further development of porphyry copper deposits is low.