Objectives: Zhaishang gold deposit is an important super-large scale Carlin-like gold deposit in the west Qinling tectonic belt of China. Previous studies on this gold deposit mainly focus on mineral deposits, geochronology and metallogenic characteristics. It is important to systematically review the geophysical work in the study area to summarize the ore-occurrence rules and expand the deep prospecting space. Methods: In this paper, the deep structure of Zhaishang gold deposit is studied by using CSAMT and electromagnetics throughout the study area. Combined with regional geophysical anomaly and geological data, the typical geology-geophysical interpretation model is established to discuss the metallogenic mechanism and summarize the occurrence regularity of orebody. Results: The study shows that the Zhaishang gold mine is generally located on the Zamashue-Zhuoluo anticline. Taking the deep and large faults as the boundary, the region is divided into two parts, the south and the north ore belt, which have different metallogenic conditions and deep electrical structure. Furthermore, a set of comprehensive geophysical prospecting methods applied to deep prospecting in Zhaishang gold deposit is formed, which has been verified in the shallow overburden areas in the east-west extension direction of the south ore belt. Conclusions: Only through multi-scale and multi-method geophysical exploration can we provide a reasonable and comprehensive geological interpretation for complex large mining areas. The results show that there is no large-scale magma intrusion near the surface, and the source of the mineral is mainly related to the regional deep and large faults. The tectonic weak parts of Zhaishang gold deposit is ore-controlling and ore-bearing structure with good regional metallogenic potential.