Objectives: Northern Guangdong is an important graniterelated uranium ore concentration area in China, for a long time, the huge time difference between granites and uranium ores has led to the ambiguity of uranium metallogenic dynamics, and the genesis of uranium deposits has multiple hypothesis. Methods:On the basis of the research progress of uranium deposits in northern Guangdong, this paper aims at the unique basin—mountain system formed since Mesozoic—Cenozoic and the internal genesis of uranium deposits in this area, Combing the multiple compressional—extensional coupling evolution process and uranium metallogenic dynamics of rock massfaulted basin from a unique perspective.  Results:it is considered that hydrothermal uranium deposits in the area have the characteristics of "nonorogenic" mineralization characteristics, and their metallogenic process is controlled by the combination of remelting uraniumrich granite and deepsource fault activity in NEtrending faulted zone. Neither granite magma activity nor regional fault depression activity can lead to independent mineralization. At the same time, it is considered that the deepsource fault depression marked by NEtrending Nanxiong fault basin in 95 Ma period is the main driving force of uranium mineralization, and the late vein magma does not directly participate in mineralization. However, it plays an important role in the activation and precipitation of uranium.  Conclusions: Uranium oreforming fluid comes from the mixture of early compressional fracture toughness metamorphic thermal fluid and later tensional fracture meteoric water in the deep part of rock mass. Oreforming fluid is easily mineralized at NW, NNW faults clamped by NEtrending fault zone and unconformity interface of red basin basement. Therefore, it is an important prospecting direction.