Lithium isotopes are one of the newly developed non-traditional stable isotope tracers.This isotopic system has been gaining increasing interest in fingerprinting geologic and geochemical processes.At present,lithium isotopic solution analyses mainly include thermal ionization mass spectrometry (TIMS) and multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS).Compared with TIMS,MC-ICP-MS has many advantages,such as higher analysis accuracy and precision,less sample consumption,faster analysis speed and so on.Methods: In recent years,the research team have established high-precision measurement of lithium isotopes by MC-ICP-MS, which has achieved good results in the determination of lithium isotopes in natural samples,reference materials and quartz inclusions. Results: Based on these analytical methods,we have established the Li isotopic geological endmembers,which are applicable to the study of the origin of local rocks in Tibet.In addition,we have applied Li isotopes to the lithospheric structure and uplift history of the Qinghai—Tibet Plateau,the enrichment mechanism of carbonatite-type rare earth deposits in western Sichuan,the source of ore-forming fluids of Gacun volcanogenic massive sulfide (VMS) deposits in Sichuan and the enrichment mechanism of Jiajika hard-rock lithium deposits in Sichuan.Conclusions: In this paper,we present these representative applications in detail in order to deepen the understanding of lithium isotopic solution analysis and show its good application prospects in geochemical research.