The Shanggaojia village comprehensive anomaly(magnetic and radioactive), which is located at the northern part of Shiquan County Ankang City, Shaanxi Province, is optimized for further study based on the latest airborne geophysical data of southern Qinling Mountains research area, in order to find and improve the aero geophysical deep prospecting method. It should be combined with the characteristics of lithology, structure and surrounding mineralized points, and optimized according to certain conditions. It is found that the northeast part of the anomaly is mainly composed of metamorphic sandstone, and the southwest part is mostly mica—quartz schist, by multiple methods surveying on the ground in profile form, including magnetic, gamma- ray spectrum, rock (ore) physical properties, and basic geological work. The Uranium radioactivity content is higher on the side of metamorphic sandstone near two types of lithologic junctions, with the maximum measured on the surface is not less than 70×10-6eU. It is speculated that the Uranium anomaly is mainly caused by metamorphic sandstone, and the magnetic one is caused by metamorphic schist (original rock is volcanic rock) with a relatively larger buried depth. There is positive prospect for the formation of iron, copper, uranium and so on, supported by the mineralization signs found in the collected samples through professional identification. The anomalies are optimized from the aero data, so as to effectively focus on the key areas on the ground. After that, the cause of the anomaly is realized by means of data analysis, field measurement, sampling and other verification methods. It is an efficient working mode to study the concealed deposit and delineate the metallogenic prospect area.