Objectives:The study area is located in Danzhai—Sandu mercury—gold mining area. However, there are few studies on soil—maizes system in Danzhai—Sandu mercury mining area. The geochemical characteristics of soil—maize system elements and the enrichment mechanism of Se, Mo and Zn in maize were studied in this paper. Methods: Field investigation and systematic sampling are conducted in this paper. The elements in soil and crops were analyzed by ICP- MS and ICP- AES, the pH value of soil was determined by PHS- 3C pH meter, and the correlation between elements was analyzed by SPSS. Results:The contents of heavy metals in maize were lower than the standard which included GB 2762- 2017, EU and WHO/FAO. The soil single factor and comprehensive pollution index showed that the soil was contaminated by As, and the soil comprehensive pollution index averaged 2. 17, which was moderately polluted. The orders of ten heavy metals enrichment factors and transfer factors in maize are Zn>Sn>Se>Mo>Cd>Cu>As>Hg>Pb>Cr and Zn>Mo>Cu>Cd>Sn>Se>As>Hg>Pb>Cr, respectively. The enrichment factors and transfer factors of Se, Mo and Zn in maize were 0. 2432, 0. 0658, 0. 2164 and 0. 1056, 1. 3669, 1. 8051, respectively. The health risk assessment of maize showed that the HQ values of heavy metals in adult corn were less than 1, while the HQ of children As was greater than 1, and the HQ of other heavy metals was less than 1, which had not threatened human health. Conclusions:The contents of heavy metals such As and Hg in the soil of the mining area are higher, exceeding the background values of Guizhou and China, while the contents of heavy metals such As and Hg in corn are lower, while the contents of beneficial elements Se, Mo and Zn are higher. And the correlation analysis shows that the correlation between Se, Mo, Zn elements is obvious, and the correlation between Se, Mo and Zn elements is not obvious, which may be related to the mining area soil rock weathering, It can be seen that under alkaline conditions, Se, Mo, Zn elements are easy to migrate, while As, Hg, Cd elements are not easy to migrate, leading to the enrichment of Se, Mo, Zn in corn, and the loss of As, Cd, Hg and other elements.